Applications
Biomarker Discovery      

NanoLC and MicroLC for Increased Peak Resolution and Sensitivity

     

Programmable Voltage for Optimizing Charge States for MS/MS Sensitivity

     

Minimal Sample Consumption

     

Fast method development with programmable voltage and dual column capabilities

The AutoNano is uniquely suited for obtaining maximum sensitivity of peptide biomarkers. Biomarkers, useful for understanding medical disorders and the effectiveness of treatment, are generally present in biological matrices at <1pg/mL levels. Increasing sensitivity through the use of both nanoLC-MS and microLC-MS, and the optimized programmable voltage of multiply charged peptides allow the maximum obtainable sensitivity in targeted MS/MS analyses. This chromatograms below were obtained by the AutoNano’s programmable high voltage power supply which drives multiply charged peptides to the highest charge state in conjunction with an optimization of capillary voltage, cone voltage, and mobile phase composition for each peptide in a chromatographic method.

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Nanospray analysis of neuropeptides
Angiotension II, Leu-enkephalin, Met-enkephalin, a-Endorphin
Method development - Programmable Voltage Optimization
Leu-enkephalin

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Videos
The µAutoNanoLC System: Active Spray Control Demonstrated

Dual-column Spray: Automated Column Switching
Live video shows automatic switching from one column to another. The Dual Column Source automatically positions a new column, the spray purges and clears for virtually uninterrupted electrospray. 1 min 3 sec

Active Spray Control “Bubble Buster” Technology Explained
Animation illustrates how Active Spray Control technology senses air bubbles and automatically reacts to prevent spray interruption. 35 sec

Active Spray Control Bubble Buster Live
Live video of Active Spray Control in action, sensing and adjusting to maintain consistent electrospray delivery. 40 sec

ASMS - May 23-27, 2010 - Booth #100 - Presentation and Posters Monday & Tuesday, May 24 & 25, 10:30am - 2:30pm

Phoenix S&T introduces the µAutoNano LC and column heaters
Events & News Releases
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